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In cells, enzymes are the basis of the natural circuits that switch genes on and off, maintain biological rhythms and produce molecular answers in response to environmental stimuli.
"This is a cool study that shows you can harness the power of natural circuits that have evolved over a very long time," says bioengineer Jim Collins of Boston University.
Here we discuss the diversity of these natural circuits, which use γ-butyrolactones (GBLs) as their main inter-cellular signal, highlighting the range of new building blocks they could provide, as well as a number of exciting recent applications of GBL-based circuits in heterologous systems.
Many of the "less natural" circuits are dominated by huge financial sponsors, whereas this natural league appears to be driven purely by passion.
Our results can help understanding the essential role of autoloops in small natural circuits and their synthetic counterparts.
That said, I think this will serve as a nice example to which other synthetic and natural circuits can be compared.
Similar(52)
VTB complies with a simulation standard named VHDL-AMS to enforce natural (circuit), signal, and data coupling between entities from diverse disciplines.
Be clear upfront in the Title and the Abstract that this is a study of a synthetic circuit, not a natural circuit.
It is worth pointing out that the analysis here is relevant not only to natural signalling circuits but to synthetic circuits as well.
A high speed and low power CMOS current-mode current-controlled-gamma corrector composed of three approximating natural logarithm circuits and two approximating exponential circuits is proposed.
Because signal transduction mechanisms are the natural control circuits that regulate biological systems, they provide potent targets for development of therapeutic agents to combat disease or otherwise alter the behavior of biological systems.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com