Sentence examples for natural backbone from inspiring English sources

Our method is inspired by the observation that the medial axis, being the skeleton of an object, serves as a natural backbone structure of the object to improve its resistance to external loads.

In combination with a natural backbone of the primary miR-30 microRNA (miRNA), higher amounts of synthetic shRNAs can be produced from the pol III promoter than from the simple hairpin design [12].

The CpG ODNs developed in this study consist of only a natural PD backbone, which may eliminate the side effects introduced by the PTO backbone modification.

To check whether the observed difference extends to INH-ODNs synthesized with the natural PO backbone, INH-1 and INH-18 were made with the PO backbone.

Various chemical modifications have been introduced in the natural oligonucleotide backbone of aptamers in order to increase their half-life, as well as their pharmacological properties.

As the natural phosphodiester backbone of RNA and DNA is particularly susceptible to nuclease degradation, the chemistry used for each nucleotide in early studies that used AOs was unstable and generally ineffective.

PNA is a DNA analog in which the natural phosphodiester backbone of DNA is replaced by a 2-aminoethyl-glycine linkage.

When INH-ODNs were made with natural PO backbone and tested at concentrations of up to 10 μM, neither class B nor class R INH-ODNs could inhibit R-837-induced activation of RAW cells or IgM secretion from primary B cells (data not shown), suggesting a PS backbone-dependent inhibitory effect on TLR7 activation, not affected by base sequence.

Furthermore, PMAP is resistant against enzymatic hydrolysis due to its non-natural polypeptoide backbone, a desirable property when imaging processes in a whole lysate where the presence of protease proteins are unavoidable.

Type A(D) CpG-ODNs contain poly-G rich tails and a central palindromic CpG sequence with the natural phosphodiester (PO) backbone.

It was based on the backbone of natural miR-155 in which the natural miRNA:miRNA duplex sequence was replaced by the artificial one.