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It could be said they more often belong to the "natively unfolded" category [ 30] than native proteins do.
Natively Unfolded FG Repeats Stabilize the Structure of the Nuclear Pore Complex.
Therefore, the stabilization of non-structural natively unfolded status is important to prevent α-synuclein fibril formation.
Barnase GCN4 is thus a "natively unfolded" protein that uses ligand binding to switch between partially folded forms.
Denning, D. P., Patel, S. S., Uversky, V., Fink, A. L. & Rexach, M. Disorder in the nuclear pore complex: the FG repeat regions of nucleoporins are natively unfolded.
Natively folded proteins contain hydrophobic cores formed by the packing of hydrophobic surfaces, while natively unfolded proteins are rich in polar residues.
It is a natively unfolded protein present mostly in the cytosol.
The vast majority of natively unfolded polypeptides have been shown to form fibrils of amyloid nature.
These are characteristic features of natively unfolded or intrinsically disordered proteins.
They may be unstable, sticky, or perhaps natively unfolded in the absence of other exocyst subunits.
It is natively unfolded but does not self-aggregate unless it is present at very high levels [19].
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