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In addition to the native turn residues, the cyclic peptides include a linker unit between the N- and C-termini, selected by molecular modeling among various non-proteinogenic cyclic amino acids.
If aggregation proceeds from an unfolded conformation, and the native turn structure is not preserved in the aggregates, the effect of a specific turn sequence on aggregation would be directly correlated with its effect on the β-hairpin stability.
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Nokia will provide native turn-by-turn in upcoming WP8 devices, including offline support.
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