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The sweeping timescale of its story, from ancient glory to medieval decline, from Ottoman empire to British occupation, from socialist revolution to modern money-grabbers, is held together by a loose, connecting thread: the contrast and conflict between cosmopolitan, multi-faceted Cairo and its traditional, native heart.
Patient survival to transplantation or native heart recovery was 68.4%.
In the native heart, anisotropic tissue structures facilitate important concerted mechanical contraction and electrical propagation.
Native heart valves are durable because valve interstitial cells (VICs) maintain tissue homeostasis by synthesizing and remodeling the extracellular matrix.
Our strategy could provide prerequisite information to construct a 3D-engineered heart, functionally comparable to the native heart.
Layered cardiomyocyte sheets in vivo present long survival, macroscopic pulsation and characteristic structures of native heart tissue.
The scaffolds showed anisotropic bending moduli depending on the loading directions (lower when with curvature than against curvature), which mimicked the characteristic behaviour of the native heart valves.
The bi-layer scaffolds have represented a forwarding step to the tri-layer scaffolds that more closely resemble the native heart valves.
First-generation LVADs are volume displacement pumps, which function by mimicking the native heart and can be implanted intra-, extra-, or paracorporeally.
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These data indicate that tissue-engineered myocardial tubes have native heart-like structure and function.
Site of infection in study patients included pulmonary, urinary, abdominal, soft tissue, and native heart-valve infections, as shown in Table 1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com