Sentence examples for native genomic from inspiring English sources

Additionally, repeat mutations are investigated in their native genomic environment and for multiple genomic loci (eventually genome wide) simultaneously.

CRISPR/Cas9 technology would enable such studies by altering single SNPs in the genome of a model organism while maintaining the native genomic context of the variant.

Whether using physical maps or the whole genome shotgun sequencing approach, the sequencing exercise involved randomly fragmenting either cloned (copied) or native genomic DNA into very short segments that could then be inserted into bacterial cells as plasmids for amplification, producing many copies of the segments, prior to nucleic acid purification and sequence analysis.

Until recently, the analysis of enhancer activities at their native genomic locations was low throughput, laborious and time-consuming.

Thus, although the dominant mutations may destroy the essential function of the plasmid-borne variant, alteration of the transcriptome with minimal perturbation to normal cellular processes is possible via the presence of the native genomic allele.

Where indicated, we also derived revertant BACs in which the mutant locus was replaced by the native genomic sequence.

We report the use of a base-specific heteropolymeric triplex, formed by native duplex genomic target and an oligonucleotide third strand probe, to assay for low copy pathogen genomes present in a sample also containing human genomic duplex DNA, or to assay human genomic duplex DNA for Single Nucleotide Polymorphisms (SNP), without PCR amplification.

We attribute this increased width to the recent admixture in populations of the New World, where European, African, and Native American genomic ancestry may be observed in various proportions in different people.

Furthermore, in the native A-rich genomic context, even short repeats such as (GAATTC 9 sequences, can readily form a YRY triplex [19].

To allow detection of the XopD protein that is produced by Xcv from its native promoter, Xcv genomic DNA was tagged with an HA epitope at the 3'end of xopD coding sequence using a suicide vector.

This marine vertebrate endonuclease showed activity against native and denatured genomic DNA, and a half-life of 10 min at 50°C with total loss of activity after 10 min at 60°C [20].