Sentence examples for native flexibility from inspiring English sources

New data emphasize a breadth of possible structural mechanisms, particularly the ability to drastically alter protein architecture and the native flexibility of many structures.

Conformational states extracted from the simulations of the wild-type YscD monomer were used to take into account the native flexibility of YscD and eventually to build the final assembly.

Then, these data supports that in general mutations function as native state flexibility amplifiers and subsequently they can facilitate the access to alternate conformational states.

The obtained trajectories were analyzed in terms of changes on the native state flexibility, the internal dynamics and coordination properties of the fold, the solvent exposure of α3 methionines (M205, M206 and M213) and the energetics of the protein surface in relation to the definition of interaction patches linked to aggregation/self-recognition processes.

Pontano wrote Latin as if it were his native tongue, with unusual flexibility, smoothness, and humour.

As far as the CD4bs is concerned, all approaches using the whole gp120 protein have been of limited success due to the high flexibility of native gp120.

Using all-atom molecular dynamics (MD) simulations of HuPrP(125 229) and of its oxidation variants, we have found that the oxidation of M213, M206 or the combination of both dramatically changes the global dynamics of the native state, increases the flexibility of specific regions, and alters the network of stabilizing interactions typical for the folded state.

Using molecular dynamics simulation, essential dynamics, correlated motions and signal propagation analysis, we have found that substitution of the sulfur atom of M213 by a sulfoxide group impacts on the stability of the native state increasing the flexibility of regions preceding the site of the modification and perturbing the network of stabilizing interactions.

MDS results showed more flexibility in native Tyrp1 structure.

It was further indicated that native structure has more flexibility than mutant (R326H and R356Q) structures.

Interestingly, we can leverage the native structural and chemical flexibility afforded by the modular construction of metal-organic frameworks to tune this critical point.