Further, the modest effects from several mutations suggest that there are multiple pathways for escape from Itrap and that escape is aided by loosening nearby native structural constraints, presumably to facilitate local movements of nucleotides or segments that have not formed native contacts.
Wolff admits this "slowed down development", because engineers had to learn these new mobile mediums, and because building for mobile naturally takes longer because of device and native app constraints.
Analysis of the changes in conformational dynamics of PYP between light and dark states suggests that none of the native loop constraints change dramatically.
On the other hand, the inclusion of Cβs is motivated to provide additional native-state constraints to limit the folding search space when Cα alone gives too much conformational freedom and often results in meta-stable configurations not observed in experiments (Ding et al. 2002).
The free energy landscape is defined using two order parameters: the number of native torsion-force constraints, N nt, and the number of H-bond constraints, N hb (see Fig. 1a).
Knee kinematics after total knee arthroplasty is dictated primarily by implant geometry and native soft tissue constraints.
Proceeding from left to right, θ will decrease since the protein rigidifies as more native torsion force constraints are added.
Examining the cases of Élisabeth Vigée-Lebrun, Jacques-Louis David and Francisco de Goya among others, this course focuses on the works artists produced while away from their native land, often by constraint rather than choice.
We tend to believe that gene conversion occurs at a much higher frequency in the intron and HEG regions than in the exon region, largely because group I introns are likely under less functional constraint than native protein coding sequences.
But to serve largely subsistence farmers, they have to compete against the local startups — particularly on cost of service in a highly fragmented business, with no easy path to scale, owing to illiteracy, language, border constraints, and native dogmas.
Recent studies have found that many non-native animals and plants can shift their climate niches from invaded ranges due to the release of historical and geographical constraints from native ranges or because of evolutionary changes in climate niche to new ranges [22], [23].
