Sentence examples for native basement from inspiring English sources

Indeed, in melanoma cells, p85β depletion reduced the z-length of cell adhesions, their GTP-Cdc42/Rac levels, and cell invasion in collagen and in native basement membrane.

They use a native basement membrane to determine which cell type cancer cells or fibroblasts is degrading basement membrane and whether distinct subpopulations of fibroblasts have different effects.

However, the basic homogeneous structure of the connective tissue (Wolf et al, 2009) and lack of a native basement membrane (Chung et al, 1997; Yadev et al, 2011) in collagen-based models allows only a simplistic representation of the native stromal component.

This EHS sarcoma extract contains basement membrane components that reconstitute into a loose matrix stabilised predominantly by non-covalent interactions, but in critical contrast to native basement membranes, MMP activity is not required for cell penetration (Even-Ram and Yamada, 2005; Hotary et al, 2006).

Here, we present a method that combines the use of (i) topographically patterned substrates (mean pore diameter 800 nm) possessing features that approximate those found in the native corneal basement membrane; and (ii) EFs (0 150 mV mm−1) mimicking those at corneal epithelial wounds that the cells experience in vivo.

To confirm p85β requirement for cell invasion in a more physiological setting, we isolated native peritoneal basement membrane from C57BL/6 mice and tested the ability of control, p85α- or p85β-depleted BLM cells to degrade the basement membrane.

Some include native collagen and intrinsic basement membrane proteins and fibroblasts, others are based on xenogeneic collagen or synthetic supports often without fibroblasts.

At 20 weeks a proliferative phenotype was observed with increased fibroblast markers, further collagen deposition and loss of basement membrane and native cell markers.

MMPs show a wide range of specificity for various substrates, which include: native and partially degraded fibrillar collagens, basement membrane collagens, proteoglycans, elastin, and fibronectin.

Mucosal models that utilise a more complex, native, connective tissue containing a defined basement membrane to investigate oral dysplasia and invasive carcinoma may provide a greater insight into the molecular mechanisms controlling premalignant dysplasia and invasion in vivo.

"There's shorter Russian literature out there," Dale reminded me as tourists and local natives walked around the store's basement and the two stories that rose above it just as they had for over 50 years.