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In vitro release studies demonstrated prolonged nicotine release from the nasal insert formulation compared to a powder and liquid.
In conclusion, the nasal insert displayed a promising prolonged plasma profile, which must be investigated further to provide statistical significance to prove the effect.
The in vitro and in vivo characteristics of a nasal insert formulation prepared by lyophilisation of a viscous HPMC gel solution designed to overcome this problem were studied.
Nicotine formulations were administered to eight wether sheep in a randomised four-way cross-over study, and plasma nicotine assessed comparing the nasal insert formulation with conventional nasal powder, nasal spray and IV doses.
When the nasal insert comes into contact with the highly vascularized nasal mucosa, it absorbs water and swells.
In situ release study of loaded nasal insert was carried out by using Keshary-Chien Franz diffusion cell.
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The nasal inserts help to reduce the amount of water lost through exhalation, condensing the moist air from the lungs and returning it to your body when you inhale.
The structure of the nasal inserts depends on the composition of CH-CS complexes.
All the nasal inserts hydrated over a period of 8 h.
Nasal inserts, a promising drug delivery system, are prepared by lyophilization of polymers.
The water uptake ability of all the nasal inserts is summarized in Table 1.
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CEO of Professional Science Editing for Scientists @ prosciediting.com