Instead of narrowly studying only one disease, each team had the latitude, within a broad category, to focus on any drug targets or diseases they wanted to.
We present here a detailed comparative analysis of the less studied and narrowly distributed CslB/H/E/G/J families.
Such an assessment may take various forms, including very narrowly focused studies, assessments that evaluate exposures to multiple stressors to facilitate cumulative risk assessment, or assessments that focus on vulnerable or susceptible populations.
Despite different lithostratigraphies, the mineralogical compositions for all studied outcrops cluster narrowly in the fields of subarkose and lithic subarkose; the Leistadt samples show an increased amount of lithic components (Fig. 3).
However, there is a strong need to fractionate and collect larger quantities so that fundamental properties of the more narrowly dispersed fractions can be studied using additional characterization methods and for subsequent applications.
Authors' response: See response to Reviewer 2. In a sense, the article, and specifically Figure 1c, questions the validity of the arCOG database, or at least shows that it is, at least for the protein family studied here, too narrowly in its definition of orthologous groups.
A more narrowly focused study by Grant Miller shows that newly enfranchised women voted for candidates who supported new public health-care programs that significantly reduced child mortality.
Narrowly restricted studies with questionable external validity need not be the norm.
Further, our implementation choices highlight the trade-offs between internal and external validity in narrowly controlled studies.
One is that systematic evaluation of the community response may have more value than highly technical and complex but narrowly defined studies.
