It is characterised by degradation of the joints, including cartilage surfaces and subchondral bone, causing joint-space narrowing, pain, stiffness, swelling, tenderness and reduced physical function.
Molecular investigations revealed an increase in relevant signalling molecules for osteoblasts that were consistent with differentiation studies, but detected the presence of tenoblast markers on collagen substrates within a narrow range of stiffness.
Thus, ECMs of optimum ligand density are required to cause a positive propulsive force and promote migration, and the steepness of this optimum depends strongly on ECM stiffness (note the narrower range of allowable ligand densities on softer ECMs in Fig. 5B).
However, SynFix-LR® was reported to exhibit a narrower elastic zone and stronger stiffness in the axial rotation.
Primary human hepatocyte viability and phenotype were determined over a narrow physiologically relevant range of substrate stiffnesses from 600 to 4600 Pa in both the presence and absence of liver ECM.
Affected joints can develop arthritis, which manifests itself by inflammation accompanied by a degree of stiffness, pain, swelling, and narrowing of range of motion.
It's theoretically possible to build a wheel suspension that could constantly adjust its stiffness to create the perfect narrow-track vehicle.
This trend requires narrower micro-probes, which in turn reduces the stiffness of the micro-probes.
It was found that the higher the stiffness of the host structure, the narrower the isolation bandwidth is in the vicinity of the resonance frequency.
Complications of cross-link formation include decreased elasticity and increased stiffness of vessels, increased thickness and rigidity, narrowing of the vessel lumen (McNulty et al. 2007), development of sclerosis of renal glomeruli and atherosclerosis.
