Core temperature in horses is normally regulated within narrow limits.
In this respect, a detailed functional inspection of the impact of the distinct 3'-flanking sequences [25] on gene regulation might help to further narrow down repertoires of similarly regulated rif-genes.
LysR type transcriptional regulators, of which LrhA is a member, are widely distributed among bacteria, and can respond to specific signals to regulate narrow and broad regulons, which can include genes involved in virulence, metabolism, and other behaviors [ 59].
Cue-induced local mRNA translation is a dynamic process regulated in a narrow time window.
In general, broad promoters have been associated with developmentally regulated genes whereas narrow promoters are associated with tissue specific expression [ 14].
Although s-Ca2+ istrictlyly hormonally regulated within a narrow range, the levels were statistically significantly higher in the Pakistanis than in the Norwegians.
Furthermore, we used the false discovery rate (FDR) procedure to remove false-positive data from the candidates of significant expression change data and narrow the candidates for genes regulated by each of the TFs [ 17].
General concerns with the RCTs for DrotAA are that they were tightly regulated, included a narrow range of patients and centers, applied restrictive treatment protocols, focused on short-term endpoints (28-day mortality), and did not collect cost data.
Although FG levels seem tightly regulated within a narrow range by a feedback mechanism that targets a particular FG set point for each person (24), FG levels vary substantially among nondiabetic populations, and an estimated 25 40% of the variation may be explained by genetic factors (7).
These techniques are sensitive to differential expression as well as small concerted changes in levels of gene expression, yet they may not adequately address changes with respect to the global behavior of gene expression – where transcript levels may either be tightly regulated within a narrow range, or fluctuate widely as a function of environmental cues or tissue specialization.
