Data obtained from those studies allowed us to quickly narrow down the formulation approaches.
The micellar formulation showed narrow but significant improvement in reduction of IL-6, while its higher suppression rate of TNF-α was not statistically significant.
The low polydispersity index for various formulations indicated narrow size distributions.
However, high throughput methods have been recently developed that allow rapid screening of large numbers of combinations of plants, pretreatment conditions, and enzyme loadings and formulations to narrow the field to those with high sugar release or other desirable features [ 28- 34].
Several current treatments interact unfavorably with other medications, and have resistance problems, a narrow spectrum of activity, limited formulation, toxicity, and also some are fungistatic as opposed to fungicidal (Groll and Kolve 2004).
The PDI was found to be <0.2 for both formulations, indicating a narrow size distribution of particles and, consequently, a uniform distribution.
Many studies have attempted to determine the optimal particle size for ophthalmic formulations, and a narrow size range ensures a lower level of irritation, adequate bioavailability, and good compatibility with ocular tissues [29].
The results of optimized formulations showed a narrow size distribution with a polydispersity index of 0.01%, an average diameter of 207 ± 26 nm, and a drug loading of more than 30%.
In contrast, the cationic serine protease cathepsin G was inhibited by oleic acid within a narrow range of oleic acid cotton formulations.
The size distribution of DOPC/SS14, DMPC/SS14, and DOPC/DOPE/SS14 liposomes was markedly narrower than that of DMPC/DMPE/SS14 formulation for which a main population with mean diameter centered at 110 nm could still be evidenced (70% by integrated intensity).
