This poses no problem at the low expression end, but at the high expressions the density of genes within a narrow expression interval is small and a certain number of genes (probe sets) must be excluded.
We adapted the tissue specificity index, τ. to investigate how narrow Nups network genes expression is across development: where N is the number of stages being compared, E i is the expression in stage i, and Emax is the maximum expression reached by the gene across stages (Yanai et al. 2005).
This expression is narrower than QoL because HRQoL only focuses on the influence of health and disease [ 4, 5].
Its range of expression is fairly narrow.
In contrast, we do not find any sex bias for sex determining region (SRY, zsex = 0.08), which initiates the sex differentiation cascade, probably because its temporal expression is very narrow, 10 – 12 days post coitum in the mouse [ 22].
Hybridization of Ihh showed no obvious differences in mutant tibiae relative to controls (Fig. 6C, D), suggesting that the narrower zone defined by Col2a1 expression is predominantly due to a reduced proliferating chondrocyte zone.
In the normal liver, GS expression is limited to a narrow rim of hepatocytes around the central vein [35, 36].
An empirical expression is obtained for taking into account the weak influence of curvature ratio on narrowing the RTD.
Our results indicate that ohnologues with slower rates of evolution and wide expression ranges are associated with slowly evolving tissues, whereas SSD genes with faster rates of evolution and narrow range of expression are associated with fast evolving tissues.
