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We found evidence of rapid evolution in genes with narrow expression, especially for those expressed in the liver and mammary gland and for genes coding for secreted proteins.
We attempted to see if genes coding for secreted proteins and genes with narrow expression, specifically those preferentially expressed in the mammary gland, have diverged at a faster rate between domestic cattle (Bos taurus) and humans (Homo sapiens) than other genes and whether positive selection is responsible.
As might be expected from their frequent narrow expression specificity, lincRNA loci are substantially depleted in broadly expressed euchromatin ("yellow", fig. 3 C ) and in HP1-associated heterochromatin ("green", fig. 3 C ).
Instead, they are mainly housekeeping genes (τ < 0.4) expressed in many tissues or, if they do show narrow expression (τ > 0.7), their tissue of highest expression is not the brain.
In addition, broadly expressed protein-coding genes are more conserved than those with a narrow expression profile [ 31].
As our knowledge of cellular proteins manipulated by HIV-1 expands, we expect that more proteins will be discovered that exhibit similar characteristics to Mov10 these being a narrow expression window in which HIV-1 is capable of reproducing.
Similar(24)
From recognition of basic similarities one might reason to a sort of monotheism, by the lights of which, for persons given to theology, local deities were no more than narrow expressions of greater truths.
It is not clear that we will be able to find enough purely narrow expressions to do all the descriptive work we need.
PCI-negative (PCI-) genes exhibit higher evolutionary rate and narrower expression breadth than PCI+ genes (p<0.001), consistent with more frequent tissue-specific inactivation.
Interestingly, the more slowly evolving brain-related genes have wider expression while the rapidly evolving immune-related genes have a narrower expression pattern.
Narrower expression breadths were associated with a larger percentage of recent SSD genes (KS < 1.0, red), whereas the percentage of ancient SSD genes (KS ≥ 1.0, pink) was nearly constant regardless of expression breadth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com