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In some circumstances the combined uncertainty, particularly over the long term, makes it difficult to determine the balance of costs, co-benefits, and co-harms, but additional methods can help narrow estimates substantially, particularly in the near term.
15 Meta-analyses of small trials can provide evidence of benefit with what seem to be narrow estimates of precision; however, such reviews have often been subsequently refuted by large trials.
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If possible, larger studies should be conducted to provide narrower estimates of this failure rate.
In December, app analytics company Distimo claimed that the revenue gap between Apple's App Store and Android's Google Play store was narrowing, estimating that on a typical day in November, global revenues for the 200 top grossing iOS apps were more than $18m versus $12m for the comparable selection on Google Play – compared to $15m and $3.5m respectively a year before.
The numbering (1, 2, and 3) corresponds to the configurations shown in Figure 3 figure supplement 2. This analysis provides the narrowest estimate for the range of N w for each data point Δ x (colored bands).
Coronary artery disease was defined based on angiographic criteria as the occurrence of at least one stenosis of at least 50% in at least one of 15 coronary segments, using the maximal luminal narrowing estimated by standardized visual analysis.
The severity of coronary artery disease is stated in the Research Design and Methods section (2): "Coronary artery disease was defined based on angiographic criteria as the occurrence of at least one stenosis of at least 50% in at least one of 15 coronary segments, using the maximal luminal narrowing estimated by standardized visual analysis".
For the narrow prevalence estimates, the NVVRS and VES both obtained estimates of 0.0% while for the broad estimates, the two studies yielded estimates of 8.3% and 4.8% respectively.
There were several traits for which we found no significant dominance component, resulting in equal broad and narrow heritability estimates.
For the male Vietnam-Theater-Veterans, the narrow prevalence estimates for the NVVRS and VES were 2.9% and 2.5% respectively.
As such, ignoring the dependence of spatial data can lead to an underestimation of SEs, resulting in overly narrow CI estimates and, consequently, incorrect statistical inference.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com