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First proposals have been made in [11] for example on what is meant by broad and narrow compound class definitions, potentially also described by terms such as "derivatives", "scaffolds" or "backbone".
Although MS-based systems are very reliable and especially useful for multiresidue methods, a specific detector such as a nitrogen phosphorous detector for organophosphate insecticides or an electron capture detector for organochlorine pesticides can often be used for single analyte detection or for multiresidue methods that cover a narrow compound class range.
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In the discussion, emphasis has been laid on alkaloids, terpenoids, quinones, flavonoids and narrower compound classes of compounds with micromolar range activities against Schistosoma, Trypanosoma and Leishmania species.
For a narrow asymmetric compound channel such as ones considered here, only two panels are often sufficient to simulate the flow by SKM (Yang et al. 2012).
Lanthanide-based luminescent probes have attracted increasing attention due to their unique optical properties, such as large Stokes and/or anti-Stokes shifts, long luminescence lifetimes (up to milliseconds), and narrow and compound-independent emission bands, making them widely employed in detection, diagnosis, and bioimaging.
Narrow-spectrum compounds are ideal candidates to target a specific pathogen with minimal disturbance of the resident microflora.
In many cases, antibiotics can be stopped at days two or three or changed to narrower spectrum compounds.
Spotting muzzle flashes, the marines sited their rifles on "murder holes," narrow gaps in compound walls designed to accommodate barrels aimed from the inside out.
Examples of SVM methods include a model obtaining more than 80%% sensitivity consistently for five different protein targets [42]; however the limitation of this implementation to five molecular targets only allows for a very narrow view of compound activity.
Narrow pubic arches compound the problem and make it difficult to achieve adequate source placement in the lateral and anterior parts of the prostate.
According to the structures and docking models, the binding pocket is too narrow for the compound in Sirt3 and 5, so that it was docked with low binding energy to the surface of the respective Sirtuin.
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