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Unlike VDAs or antiangiogenic VEGF pathway inhibitors, it has an additional mechanism of action, namely, potent stimulation of host antitumour immune mechanisms (Curnis et al, 2000; Sacchi et al, 2004; Balza et al, 2006; Calcinotto et al, 2012).
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In total, 847 compounds have been discussed into three categories namely (1) potent palladium compounds, (2) palladium compounds with comparable activity and (3) palladium compounds with insignificant activity.
Structure optimization led to the identification of a highly potent inhibitor, namely DC_G16-11 withethalf-maximalmal inhibitory concentration (IC50) value of 6.8 μM.
Such understanding is crucial for making the right decisions in a timely manner and for preventing the severe potential side-effects of our very potent therapies, namely fluids, blood and oxygen.
To think that I can be sitting here, trying to write something about Ingmar Bergman and, a moment later, on the merest whim, can be watching a clip from a Swedish documentary about Don Cherry – that is a miracle (albeit one with a very potent side-effect, namely that it's unlikely I'll ever have the patience to sit through an entire Bergman film again).
Degradation of keratinous substrates was assessed by highly potent keratinophilic fungi, namely Chrysosporium queenslandicum TKKASb Apinis and R.G. Rees.
In this context, we have here engineered potent protein toxins, namely segments of the diphtheria toxin and the Pseudomonas aeruginosa exotoxin as self-assembling, self-delivered therapeutic materials targeted to CXCR4+ cancer stem cells.
CPF is a pro-poison that requires metabolic activation to become a potent phosphorylating agent, namely chlorpyrifos oxon (CPO) [3].
The principle Th1 cytokine, namely IFN-γ, is a potent stimulator of monocyte chemoattractant protein-1, which further stimulates macrophage function.
Furthermore, we recently demonstrated that the secretion of a potent angiogenic factor, namely vascular endothelial growth factor, was markedly induced by the interaction of FLS with synovial leukocytes via the integrin/ICAM-1 pathway [ 19].
Previous studies have shown that members of the C/EBP family of transcription factors, namely C/EBPα and C/EBPβ, are potent regulators of 11β-HSD1 expressinn in hepatocytes [ 26].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com