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Furthermore, even using these intensive treatment regimens, only a fraction of patients achieved the 'ideal' goal, namely halted progression and elimination of clinical activity ('remission').
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These alterations not only support the idea that senescence is preceded by an irreversible G1 arrest [30], [36], but also are reminiscent of a common function of herpesviral immediate-early genes, namely to halt cell cycle progression in G1 [18].
However, there are two major unmet clinical needs: namely to halt or prevent the rise of portal pressure before clinically significant PHT develops, and to increase efficacy, once PHT has developed, with new therapeutic targets.
The Commission, the Member States and this House must speak with one voice if the ambitious 2020 objective is to be achieved, namely, a halt to biodiversity loss plus a global vision to guarantee that ecosystems are protected, valued and restored.
"Railroads halted.
Lively halted.
This halted the unrest.
SMS transmission halted.
Here they halted, stared.
Waiters halted.
She halted.
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