10.7554/eLife.07178.009 Figure 7. Putative conservation of the naive stage during amniote embryogenesis.
Our data thus suggest that the finch blastoderm at oviposition is likely to correspond to the naive stage of embryogenesis.
In mouse embryogenesis, the naive stage is accompanied by the specific expression of a number of pluripotency-associated genes (Nichols and Smith, 2009).
Furthermore, the evolutionary distance between finch and mouse suggests that the naive stage during embryogenesis is conserved amongst amniotes and that this stage likely corresponds to the pre-epithelialized epiblast in amniotes.
Mouse data suggest that in permissive strains, ES cells can be derived from embryos at around E4 E4.5 of development, a stage that has been termed the naive stage of embryogenesis (Nichols and Smith, 2009; Boroviak et al., 2014).
Colorectal carcinomas used in this work were derived from a previously well-characterized, chemo-naive, stage II colorectal cancer cohort from Munich (Nitsche et al., 2012).
Frozen tissue samples from 29 patients who were presurgical, treatment-naive, with Stage IA or Stage IB, resectable NSCLC were studied (GSK Study VEG105290).
Akerley et al (2003) conducted a phase II trial for patients with chemotherapy-naive, advanced-stage NSCLC.
Women with newly diagnosed, treatment-naive, early-stage breast cancer were recruited for participation in the study, regardless of tumor subtype.
- In later stages, naive B cells migrate to germinal centers, where they are activated by antigen encounter and become antigen-experienced plasma cells producing antibodies or memory B cells.
