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In summary, the results support the view that naive humans use systematic exploration to solve the TOL.
Similarly, following immunization of naive humans with an MSP-142 formulation in a phase I clinical trial, T cell responses were identified against MSP-133 and not MSP-119 (Huaman et al., 2008).
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The following year Ferrell was one of the stars in Old School, and he took the lead role in Elf (2003), playing a charmingly naive human raised in Santa's village who ventures to New York City.
This study presents a framework for defining the culture requirements of naive human pluripotent cells.
Comparison with previously reported naive human ESCs indicates that our conditions capture a distinct pluripotent state in humans that closely resembles that of mouse ESCs.
Here we took a systematic approach to identify small molecules that support self-renewal of naive human ESCs based on maintenance of endogenous OCT4 distal enhancer activity, a molecular signature of ground state pluripotency.
Knowing the frequencies and affinities of HIV-specific VRC01-class naive human B cells, we transferred B cells with germline VRC01 B cell receptors into congenic recipients to elucidate the roles of precursor frequency, antigen affinity, and avidity on B cell responses following immunization.
As expected, more unique binders were isolated from the macaque immune library as from the naive human antibody gene library.
The algorithms used as reference are optimally efficient under the same constraints than naive human participants: no a priori information, and bounded memory, similar to human working memory.
In addition, the results support the view that naive human strategies and exploration algorithms are similarly affected by the combinatorial properties of the search space.
Our data obtained with populations of naive human blood cells suggest that nestin/vimentin dependent anchoring of GR appears very early in the differentiation pathway.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com