The respective allyl ethers can be synthesized through the reaction of hydroxyl end groups with allyl bromide in the presence of a base (NaOH [ 27, 31– 33], NaH [ 34], or alkali metals [ 30, 35]).
(b) NaH, 1-bromomethylpyrene, THF/toluene, 48 h, 77%.
By exploring the N-acylhydrazones (NAH) as privileged structures usually present in antiparasitic agents, we investigated a library of 16 NAH bearing the 3- 4-substituted-aryl -1,2,4-oxadiazole 3- 4-substituted-aryl -1,2,4-oxadiazole 3- 4-substituted-aryl -1,2,4-oxadiazole 3- 4-substituted-aryl -1,2,4-oxadiazole 3- 4-substituted-aryl -1,2,4-oxadiazole 3- 4-substituted-aryl -1,2,4-oxadiazole
Except for acids polyaniline could also be n-doped by strong reductant KH or NaH [129].
9 6e OPhNO2 LHMDS Quant. 10 6e OPhNO2 LDA 73 11 6e OPhNaH NaH 85 12 6e OPhNO2 t-BuOK 63 13 6e OPhNO2 Et3N 0146e6e OPhNO2 K2CO3 0 aIsolated yields by silica gel column.
In the Al Mg Na–H system, the compounds Al30Mg23, AlH3, MgH2, Mg(AlH4 2, NaH, NaMgH3, NaAlH4, and Na3AlH6 are considered as stoichiometric compounds.
The poly(NVF-co-MOENVF) (0.20 g, solid) and NaH (0.4 mmol, 0.011 g, solid) were combined in a 50-mL glass tank.
Structural examinations reveal that NaOH reacts with Mg(NH2 2 and LiH to convert to NaH, LiNH2 and MgO during ball milling.
To a solution of the PMB acetal of (R -1,2,4-butanetriol (157 mg, 0.7 mmol) in 3 mL of THF, 28 mg of NaH (60%, 0.7 mmol) was added.
Table 1 Optimization of Dieckmann cyclization Open image in new window Entry Substrate LG Base Yield a 1 6a OMe LHMDS 0 2 6a OMe NaH 0 3 6a OMe KHMDS 0 4 6b OPh KHMDS 63 5 6c OC6F5 KHMDS 95 6 6d OCH2CF3 KHMDS 83 7 6e OPhNO2 KHMDS Quant.
To our delight, 12a (nearly 1/1 diastereoisomers) was generated directly in about 40%% yield using NaH [10] with unanticipated formation of semiacetal ring which was confirmed by 1D and 2D NMR.
