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Our results support that feeding cows supranutritional Se-yeast supplement during the dry period or spiking colostrum with Na selenite both improve IgG status of Se-replete calves.
Adding 3 mg of Se/L (in the form of Na selenite) to colostrum has been shown to improve IgG absorption in Se-deficient newborn dairy calves.
Calves that received colostrum with added Na selenite had higher WB-Se concentrations for the first 2 wk, but only at 14 d of age were serum-Se concentrations, serum-IgG concentrations (53% higher), and total serum-IgG content (56% higher) higher, compared with calves that were fed colostrum without added Na selenite.
Calves born to Se-yeast-supplemented cows that received colostrum from Se-yeast cows without added Na selenite had a higher IgG absorption efficiency compared with all other treatment groups.
After birth, calves were fed pooled colostrum from control or supranutritional Se-yeast-supplemented cows to which 0 or 3 mg of Se/L (in the form of Na selenite) was added.
During the last 8 wk before calving, dairy cows at a commercial dairy were fed either 0 (control cows) or 105 mg of Se-yeast once weekly (supranutritional Se-yeast-supplemented cows), in addition to Na selenite at 0.3 mg of Se/kg of DM in their ration.
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A few compounds bypass senescence in this specific manner—acetaminophen, cotinine, nitric oxide, Na-selenite and lead.
Se, however, is present in the supplement studied in the inorganic form of Na-selenite, which shows an extremely low absorbance index in humans [ 42, 43].
Pfannenschmidt GMBH, Hamburg, Germany; grape seed oil, G. Balestrini Srl, Milan, Italy; α-tocopherol, Van Eeghein Functional Ingredients, Amsterdam, Netherlands; and Na-selenite, Giusto Faravelli SpA, Milan, Italy.
In agreement, Hazane-Puch et al. [ 31] recently reported that concentrations higher than 1.0 μM of Na-selenite exerted a cytotoxic effect on HaCaT cells.
They were kept under standard tissue culture conditions by using Ham F-12 medium containing 20%L-15L-15dium, 2% FCS, 10 μg ml−1 insulin, 2 × 10−10 M triiodotyronine, 2 μg ml−1 transferrin, 1 μg ml−1 hydrocortisone, 5 × 10−9 M Na-selenite and 30ng ml−1 epidermal growth factor (EGF).
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