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And although many of these are harmless, amongst the myriad mutants there are those whose effects are anything but benign: subtypes 6 and 11 can lead to genital warts; subtypes 16 and 18 (amongst others) can lead to cervical, vulvar, vaginal, penile, anal and oral cancers.
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Some details underscoring the challenges: 1) The inherent nature of mosaicism is that a population consists of a complex mixture of templates consisting predominantly of germline sequences intermixed with myriad mutant templates (based upon data in our manuscript showing diverse APP copies by qPCR and PNA FISH indicative of diverse genomic structures).
It is our hope the future studies that seek to identify the molecular mechanisms causing the myriad phenotypes presented in these mutants may be facilitated by the gene networks reported in this study and the multiple testable hypotheses that arise from them, for example the predicted function of sticky kinase and Fmrp in cell polarity and DNA damage repair.
talpid is an avian autosomal recessive mutant with a myriad of congenital malformations, including polydactyly and facial clefting.
Mutant HTT expression leads to a myriad of cellular dysfunctions culminating in neuronal loss and consequent motor, cognitive and psychiatric disturbances in HD patients.
Knockouts of the gene Kl result in mutants exhibiting growth deficiencies, shortened lifespan, and a myriad of other issues including bone deficiencies and hardening of the arteries [ 36].
This season involved a myriad of villains: violent nuns and a murderous priest, a serial killer, mutant zombies, a Santa Claus, a Nazi, aliens, and even Satan him(or her)self.
SGD curates and integrates a myriad of datatypes for the yeast community, including the genomic sequence; gene names, synonyms and descriptions; mutant phenotypes; genetic and physical interactions; and expression data.
As mutant HTT is not considered to be an ideal pharmacological target due to its myriad biological functions, other biochemical pathways, such as those that prevent the abnormal accumulation of unfolded proteins, represent an encouraging alternative for the treatment of this neurodegenerative disorder.
There are myriad examples.
There are myriad routes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com