The scooters can, of course, be decked out with myriad modifications and a collection of wacky weapons — I mean, why wouldn't you weaponize transportation options for those less able to work.
Although surgical shave excision with its myriad modifications has been in vogue for decades, the lack of an adequate histological sample, the largely blind nature of the procedure, and the possibility of recurrence are persisting issues.
Among myriad histone modifications, lysine and arginine methylation are well known to influence gene expression globally during development, 83 and it is likely that histone methylation is affected by nutritional status and toxin exposure, just as DNA methylation is affected.
Nucleosomes, the basic units of chromatin, are decorated with a myriad of posttranslational modifications (PTMs) by the action of chromatin modifiers.
Immediately ensuing DSB formation, a myriad of histone modifications are elicited to create a platform for inducible and modular assembly of DNA repair protein complexes in the vicinity of the DNA lesion.
In addition, a myriad of posttranslational modifications (such as phosphorylation and acetylation) can mark native proteins for regulated degradation borne out of signaling necessities [ 1].
Both histone tails and the globular domains are subject to a myriad of covalent modifications, including acetylation, methylation, phosphorylation, sumoylation, ubiquitylation, and ADP-ribosylation [ 2].
This skill is acquired through a myriad of abnormal modifications of growth factor signalling cascades and expression of their messengers and effectors.
DNA DSBs trigger a myriad of post-translational modifications that alter catalytic activities and the specificity of protein interactions: phosphorylation, acetylation, methylation, ubiquitylation, and SUMOylation, followed by the reversal of these changes as repair is completed.
Expression levels of Bcl-2 family proteins are altered, or they are targeted by a myriad of post-translational modifications driven by oncogenic signaling pathways, with an increase of anti-apoptotic or a decrease of pro-apoptotic functions.
And yet, despite evident regulation by post-translational modification and myriad other stimuli, the biological significance of many phase-separated compartments remains uncertain.
