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The scientific reason is that they are able to turn into any of the body's myriad cell types, which is why they might be used in this way.
The e-mail, dated 4 April 2013, includes detailed separate criticisms of the two papers and suggestions for new data to support the authors' claims of a simple and novel way to make stem cells that could form the myriad cell types within a body.
Both CIB1 and Plk3 are expressed in myriad cell types.
How, at the molecular level, the myriad cell types in an organism manage to stably preserve their distinct identities is an important but little understood question in biology.
The occlusion of lineage-inappropriate genes could serve to safeguard the phenotypic stability of the myriad cell types in multicellular organisms against noise in both extracellular environment and intracellular regulatory networks.
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With the notion that structure strongly dictates functional capabilities, a myriad of cell types, scaffold materials and stimulation strategies have been combined.
A further limitation is the fact that analyses of RNA and protein in this study were derived from bulk whole lung, and do not provide representation of the myriad of cell types and their organization present in the developing or adult lung.
Development of multicellular organisms requires the specialization of a myriad of cell types, each providing unique functional capabilities.
LBP is a type I acute phase response protein that is produced by hepatocytes, respiratory epithelial cells and a myriad of other cell types [10], and enhances the recognition of endotoxin and pathogens by the immune system [11].
There is a complex interplay between vascular abnormalities and inflammatory mediators, there are a myriad of different cell types involved, and, within each individual cell, there are complex interactions among multiple pathways that each have redundancy.
iPSCs have now been generated from a variety of adult and fetal somatic cell types using a myriad of alternative protocols [ 3, 6, 7].
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