Sentence examples for myogenic capacity and from inspiring English sources

These cells, named muscle-derived stem cells, possess a high myogenic capacity and effectively regenerate both skeletal and cardiac muscle.

The IM2 cell model performs more consistently than the C2C12 cell line in terms of myogenic capacity and differentiates within a shorter time-span.

Hence, non-integrative priming with Dll1 and Mef2C enhances myogenic capacity and regenerative potential of both murine and human MABs in vivo.

These data suggest that not only systemic but also local organ niches would inhibit key stem cell properties, e.g., myogenic capacity and the rate of proliferation in the aged organism.

However, Treg numbers and FoxP3 expression were low and did not change during aging, showing that reductions in myogenic capacity and increases in muscle fibrosis during aging were not likely the consequence of reductions in Treg functions within the muscle, as can occur in young, injured muscle.

Significantly, these experiments have also revealed that not only are hESCs able to protect themselves against the negative influences of aged mouse sera (Fig. 3), but these cells also produce factors that dramatically enhance the myogenic capacity of primary myoblasts and young and old satellite cells (Fig. 5), and also significantly improve repair of young and old injured muscle in vivo (Fig. 6).

Importantly, it was not simply the dilution of young serum factors that resulted in diminished myogenic capacity when young and old sera were mixed, because young sera promoted robust myogenesis both at 10% and 5%.

The difference in Dll1 epigenetic/transcriptional regulation and in Notch1 activation during the early in vitro differentiation step could account, at least partially, for the intrinsic difference in spontaneous in vitro myogenic capacity between murine and human MABs.

However, recent studies demonstrate that muscle wasting during cancer is also related to disruptions in the dystrophin glycoprotein complex and muscle fiber integrity and impaired myogenic capacity [ 6, 7], thus emphasizing the unique and complex nature of cancer cachexia.

Gastrocnemius muscles were assessed for the effect of age, gender and exercise on satellite-cell numbers and myogenic capacity.

We investigated the effects of gender, aging, and moderate-intensity endurance training, on the number and myogenic capacity of satellite cells.