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Some cardiomyopathies are primary; i.e., the basic disease involves the myocardium rather than other heart structures, and the cause of the disease is not known and not part of a disorder of other organs.
However, the density of proliferating cells at the level of the AVC myocardium was comparable to that of the ventricle myocardium, rather than to that of the wild type AVC myocardium (Fig. 6A,B and data not shown).
These data are in accordance to data obtained in patients with chronic heart failure in which progressive RV enlargement occurred in the absence of PH [16] [17], and call for a refocusing on cellular and molecular events occurring in the RV myocardium rather than in the pulmonary circulation when trying to explain the development of RV failure [11], [17].
This is suggestive of a direct impact of glucose on the myocardium rather than peripheral resistance.
Therefore, we chose to inject the plasmid into the myocardium rather than the peripheral vein or the LV chamber.
The findings indicate that the altered response of the non-infarcted myocardium, rather than baseline ventricular contractility, contributes to the T2DM-induced increase in acute mortality after MI.
Similar(44)
Our anatomical study confirmed a narrow ridge of <5 mm in majority of specimens, and the ridge had thicker myocardium superiorly rather than inferiorly [ 43].
This finding suggests that it is a sudden and abrupt change in the oxygen tension to which the myocardium is exposed, rather than a high PaO2 per se, which may be responsible for at least some of the reoxygenation injury.
In patients with ischaemic left ventricular (LV) dysfunction, those with viable myocardium should be considered for revascularization rather than cardiac transplantation, while patients with nonviable myocardium will not benefit from high-risk percutaneous coronary interventions or surgery [ 66].
In fact, studies have reported elevated MBF, rather than hypoperfusion, throughout the myocardium in patients with diabetes [ 72], and in some regions of the myocardium in patients with cardiac syndrome X [ 70].
CRP was elevated in patients with unstable angina but not in those with variant angina caused by vasospasm, indicating that CRP is associated with inflammation in the coronary artery rather than in the ischemic myocardium [ 58].
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