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They are released from necrotizing myocardium in a time-specific manner.
Myocardial cell injury caused accelerated MIBI clearance in ischemic myocardium in a canine model [31, 32].
Tc-99m-teboroxime clearance kinetics differentiate severely injured myocardium from normal and minimally injured myocardium in a canine model of acute myocardial injury due to coronary occlusion and reperfusion.
Open image in new window Fig. 9 Short-axis post-contrast T1-w inversion recovery gradient echo image shows patchy mid myocardial LGE (arrows) of severely thickened myocardium in a patient with Danon disease.
Right ventricular dilatation, abnormal right ventricular wall motion, paradoxical motion of septum and tricuspid regurgitation are typical CMR features of RV MI, although RV transient dysfunction is frequently caused by a post-infarct stunning of RV myocardium in a LV MI [3].
However, further development of these approaches is hindered by the inability to deliver the biologic agents to the myocardium in a tissue-specific, efficient and rapid manner.
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In this work a Self Organized Radial Basis Function Network (SRBFN) is designed to focus on the myocardium in an iterative process until the total extraction of the myocardium from the noisy background is achieved.
In another report, VSELs were purified from rat BM and successfully employed to regenerate damaged myocardium in an experimental rodent model of acute myocardial infarction [ 52].
For Cathepsin D, we showed that it is activated in the myocardium in an animal model of PPCM in response to conditions of enhanced oxidative stress during pregnancy in case of defective anti-oxidative mechanisms.
Thus, at the moment, a careful analysis of the presence of virus genome in the myocardium in an experienced laboratory seems to be mandatory, at least for further clinical trials in the field.
After exposure to stress, PPARα knockout mice have decreased ATP concentration with abnormal cristae of the mitochondria, abnormal caveolae, and fibrosis in the myocardium in an age-dependent manner (Watanabe et al. 2000).
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