Papillary muscle study showed decreased myocardial contractility and contractile reserve in SHR-DM.
Functional studies showed impairment of troponin interactions that could lead to diminished myocardial contractility.
There was a linear relationship between coronary sinus lidocaine concentrations and reductions in myocardial contractility.
Beca, S. et al. Phosphodiesterase type 3A regulates basal myocardial contractility through interacting with sarcoplasmic reticulum calcium ATPase type 2a signaling complexes in mouse heart.
First, cocaine acts as a stimulant in the sympathetic nervous system, increasing catecholamine levels, heart rate (HR), blood pressure, and myocardial contractility.
It may also depress myocardial contractility.
Regulation of myocardial contractility: Insights from transgenic mice.
Myocardial contractility remained without significant changes in the Sham group.
Myocardial contractility was evaluated at 1 year of age by an echocardiogram.
In summary, myocyte size, cardiac structure, myocardial contractility, and distensibility are abnormal in GH deficiency.
The extent of hyperglycemia in childhood correlates with the alteration of myocardial contractility.
