Doxorubicin (DOX) is used to treat breast cancer, ovarian cancer, lymphoma, multiple myeloma, and sarcoma [2].
Cancers with an intermediate recurrence risk (11 25%) include carcinoma of colon, breast and prostate and those with a high risk (>25%) included melanoma, invasive urothelial carcinoma, multiple myeloma and sarcoma.
As ceramide is required for cytotoxicity, this may explain why Per has had some success in myeloma, WM and sarcoma clinical trials, yet limited efficacy in other solid tumors.
Exposure to these chemicals has been linked to brain/central nervous system (CNS), breast, colon, lung, ovarian, pancreatic, kidney, testicular, and stomach cancers, as well as multiple myeloma and soft tissue sarcoma.
Zalypsis is a novel antineoplastic agent currently in phase II clinical development in endometrial and cervical cancer, multiple myeloma, and Ewing's sarcoma (http://clinicaltrials.gov/ct2/show/NCT01222767).gov/ct2/show/NCT01222767
In addition to hairy cell leukaemia and CML, therapeutic efficacy of IFN-α2 in causing at least partial disease regression has been identified in other diverse human malignancies including melanoma, renal cell and bladder cancer, lymphoma, myeloma, and Kaposi's sarcoma [ 6].
Similar associations have been shown with prostate cancer, multiple myeloma, and soft tissues sarcomas.
Subsequently a beneficial survival effect for participants has been noted in myeloma, nephroblastoma, non Hodgkin lymphoma and sarcoma trial patients (Karjalainen and Palva, 1989; Lennox et al, 1979; Wagner et al, 1995; Antman et al, 1985).
The incidence rates of VTE were higher in certain cancers, particularly cancer of pancreas (16.05 per 1,000 person-years), lung (10.20 per 1,000 person-years), liver (9.06 per 1,000 person-years), multiple myeloma (7.92 per 1,000 person-years), and sarcoma (5.08 per 1,000 person-years).
In the case of Doxil, which is used to treat ovarian cancer, multiple myeloma and AIDS-related Kaposi's sarcoma, the F.D.A. has decided to allow temporary shipments from India of Lipodox, which is similar to Doxil and is made by Sun Pharma Global.
Bone tumors can be metastatic carcinoma, osteogenic sarcoma, multiple myeloma and meningioma.
