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I am glad I didn't though, as participating in the Q&A offered me a chance to reflect and evaluate what I wanted to do and why and enabled me to begin to broaden my post-PhD strategy.
So, having secured the funding that will see me through the first 3 years of my post-PhD life, now comes the fun part--spending it!
Furthermore, the similar levels of Socs3 and Saa2 induction (downstream STAT3 targets) at 36 hours post PH, suggest that activation of the STAT pathway during the priming phase of PH has occurred normally in mutant livers (Table S3).
A single band of a 64kDa protein was observed from tachyzoite and 6-day post pH shock bradyzoite cultures of parasite lysate probed with tyrosine hydroxylase antibody (Fig. 5B).
Animals were killed at the peak of S-phase (48 h post PH) and after terminated regeneration (96 h post PH).
The inhibitory effect of Sorafenib was transient and restricted to 48 h, but not 96 h post PH.
We demonstrated that Sorafenib already inhibited hepatic S-phase at the peak of DNA replication (48 h post PH) as evidenced by BrdU incorporation analysis.
However, Harun et al. [ 28] could only confirm a significant stimulatory effect on tumor growth if the mice underwent a large 2/3 PH and the CRC cells were implanted at a relatively late stage in liver regeneration (on day 6 post PH).
Previous reports described delayed post-PH liver regeneration in hypothyroid animals [4], [28].
Consistently, elevated ADMA levels correlate with post-PH liver dysfunction [15], [41].
TRα content did not change in the period after PH; however, TRβ decreased significantly 24 72 h post-PH, returning to control levels at 96 h (Fig. 1A B).
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