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The remaining ∼33 % is of complex events that include mutually exclusively alternative transcription start sites and multiple polyadenylation sites [8], [9].
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Hence, exon 15b and exon 16 are mutually exclusive alternative exons (Figure 3B).
Mutually exclusive alternative splicing regulated through the ordered splicing recognition with tissue specific factors has been observed in nematodes [33].
Mutually exclusive alternative splicing events have long been noticed.
This indicates that mutually exclusive alternative splicing can generate diverse protein isoforms in humans as it does within insects.
Mutually exclusive alternative splicing occurs for ectodomain encoding exons 4, 6 and 9 and transmembrane exon 17 ([ 6]; Figure 1A).
This analysis examined multiple mutually exclusive alternative choices, while the primary logistic regression analysis examined binary outcomes.
It is also informative to consider the four trial treatment groups as four mutually exclusive alternative strategies for managing nAMD.
In C. elegans, the anatomical expression patterns of the mutually exclusive alternative exon variants of Syt1 have been mapped [ 103].
The vast majority of tandemly duplicated exons (99.4%) are likely to be involved in mutually exclusive alternative splicing events [ 14].
The arthropod Esyt2 genes include mutually exclusive alternative exons which serve to alter the specification of the first C2 domain.
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