Sentence examples for mutually exclusive var from inspiring English sources

The strongest evidence for mutually exclusive var expression comes from the investigation of the dynamics of transcriptional switching using episomally transfected parasites [33], [34].

Based on these novel findings, and by integrating current knowledge, we propose a speculative mechanistic model for mutually exclusive var gene activation (Fig. 6).

Antigenic variation of P. falciparum erythrocyte membrane protein 1 leads to immune evasion and occurs through switches in mutually exclusive var gene transcription.

Interestingly, the fact that this element functions autonomously in a euchromatic context implies a ubiquitous rather than spatially restricted distribution of the transcriptional activator involved, which somewhat precludes a restricted role for this factor in mutually exclusive var activation.

Together, our results show for the first time that the complex regulation of mutually exclusive var gene transcription involves functional cis-acting modules with intrinsic and position-dependent activities.

In addition, and in remarkable analogy to mutually exclusive var regulation, Lomvardas and colleagues recently described a functional association of H3K9me3 and H3K4me3 with silenced and active OR loci respectively (Magklara et al., 2011).

Epigenetic mechanisms are thought to be the main factors that regulate mutually exclusive transcription of var and stevor in P. falciparum and ensure the inheritance of transcription patterns from one generation to the next [39], [40].

Transcription of the var gene family is known to be tightly regulated and involves mutually exclusive expression of one var gene out of a total of approximately 60 gene variants.

Mutually exclusive transcription of both var and stevor has been observed in cultured P. falciparum laboratory strains [26], [29].

Here it was shown that epigenetic markers represented by specific histone modifications including both acetylation and methylation, were associated with the mutually exclusive expression of individual var genes [3], [4], [5], [9].

Although the exact function of this interaction remains to be discovered, binding of MIF to the mutual exclusion element may earmark var loci for mutually exclusive activation.