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On the other hand, if mutually exclusive splicing is regulated by the switch-like manner, the initial spliced products would consist mainly of one of the single-inclusion forms.
A regulator of mutually exclusive splicing fidelity in Dscam.
So far, mutually exclusive splicing regulation has been explained by the outcome from the balance of multiple regulators that enhance or repress either of alternative exons discretely.
So far, mutually exclusive splicing regulation is widely believed as the outcome from the balance of multiple regulators that enhance or repress either of alternative exons discretely [19], [20].
Among these, only the arthropods contain homologs arranged in tandem arrays indicative of mutually exclusive splicing.
However, the mutually exclusive splicing in these genes involves tandem arrays of three or fewer variants.
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Within PubMed and ArabiTag, which is a database to a recent very comprehensive analysis of alternative splicing events in A. thaliana[ 39], mutually exclusive spliced genes in A. thaliana are not described at all.
In the C. elegans genome 389 exons were predicted to be mutually exclusive spliced belonging to 138 genes.
In the A. thaliana genome 166 exons were predicted to be mutually exclusive spliced belonging to 66 genes.
Finally, we looked for mutually exclusive splice variants in the Scn8a gene encoding for transmembrane portions of the sodium channel Nav1.6.
These examples show that with Kassiopeia it is possible to identify many new candidates for mutually exclusive spliced genes that were not covered by exhaustive EST data sequencing yet.
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