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Expression data indicate mutually exclusive patterns of AmphiGoosecoid and AmphiVent1 genes in early amphioxus embryo, which makes the above-mentioned mechanism plausible in amphioxus as well [2].
We have shown that these mutually exclusive patterns of expression are controlled by a self-organizing system of feedback loops that involve WG and DPP, but whether the feedback is direct or indirect is not known.
The two transcription factors exhibit mutually exclusive patterns of nuclear localization in β-cell; constitutive nuclear expression of a mutant Foxo1 is associated with the lack of Pdx-1 expression [26], [27].
In this genealogy of mtDNA haplotypes, we discovered five distinct but not mutually exclusive patterns.
This is consistent with mutually exclusive patterns of positive staining for GLUT1 and Nuc-pYStat5 at the global tumor level.
SNPtool uses a comprehensive MSA to discover SNPs that show mutually exclusive patterns between two user-defined groups of genomes.
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Mehmet Altan from the University of Texas MD Anderson Cancer Center in Houston, USA, and colleagues demonstrated this mutually exclusive pattern of B7-H4 and PD-L1 activity two independent populations a finding that could explain why drugs designed to boost anti-cancer immunity by blocking PD-1/PD-L1 signaling only work for a fraction of patients with breast cancer.
Among them, we systematically identify top somatic driver candidates, including mutated FBXW7 with cancer-type-specific patterns and amplified MDM2 showing a mutually exclusive pattern with BRAF mutations.
Gata6 expression in human lung- to liver- metastases shows a mutually exclusive pattern to Gata4 (Figure 7).
Remarkably, the two transcripts, both expressed by periventricular neural precursors of the cortical primordium, display a mutually exclusive pattern in post-mitotic progenies of such precursors.
A similar relationship was found between K-Ras mutations and presence of oncogenic C-RAF, consistent with the mutually exclusive pattern of RAF and RAS mutations in human tumors [36] [37] (Figure 3B).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com