Sentence examples for mutually exclusive mutations from inspiring English sources

Mutually exclusive mutations have been previously reported for PIK3CA and AKT1 mutations [ 4].

However, we did find for the first time two cases of EGFR and BRAF coexsiting mutations, which have been previously considered as mutually exclusive mutations, as well.

More recently mutually exclusive mutations in GNAQ and GNA11, genes encoding the alpha subunit of heterotrimeric cell surface G proteins, have been reported.

We demonstrated that even though they have mutually exclusive mutations, ATRX- and DAXX-deficient PNETs have distinct genome-wide DNA methylation profiles.

In patients with JMML, Ras-MAPK signaling is constitutively activated by a spectrum of usually mutually exclusive mutations affecting genes, such as NRAS, KRAS, NF1, PTPN11 and CBL.

Mutually exclusive mutations in ATRX and DAXX are also found in neurological tumours, including neuroblastomas, paediatric glioblastomas, oligodendrogliomas and medulloblastomas (Clynes et al. 2013).

It is only valid to identify mutually exclusive mutation pairs in chromosomes that are haploid in the tumor, and we do indeed find 17 such pairs.

To identify cancer-associated chromatin factor alterations that are either synergistic or redundant, we searched for co-occurring and mutually exclusive mutation patterns, respectively (Additional file 5: Table S2).

Regarding genetic events involved in melanoma pathogenesis at somatic level, mutually-exclusive mutations of NRAS and BRAF genes were observed at quite same rate (about two thirds) in cultured and in vivo melanomas (either primary or metastatic lesions).

Thus, we expect that the genes in a pathway exhibit a pattern of mutually exclusive driver mutations, where driver mutations are observed in exactly one gene in the pathway in each patient [ 13].

These mutations are mutually exclusive with mutations in the demethylating enzyme TET2, suggesting a complementary role.