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For both tools I limited the search for mutually exclusive genes to size two and filtered the altered genes to take into account for mutual exclusivity by the list of TFs and partners integrating the circuits assessed in each tumor type.
The authors need a better illustration showing that mutually exclusive genes were enriched in top quartile of essential genes.
Experimental evolution of bacterial species constructed to have mutually exclusive genes by means of genetic engineering may be effective in verification of our models.
This report suggests how frequent the recombination events should occur among the meningococcal population: even theoretical mutually exclusive genes can produce hybrid variants; such knowledge is an important step in the development of future vaccines based on protein formulations.
This scale of analysis allows identification of a high number of new candidate oncogenes and tumor suppressors and detects highly significant combinations of co-occurring or mutually exclusive genes.
As PIK3CA and PIK3R1 are highly related (and mutually exclusive) genes within the same PI3-kinase pathway, we also combined mutation data into an additional single PI3-kinase mutations variable.
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As part of that expansion both 2DS4 and 2DL5 were moved into the telomeric region, but as part of different and mutually exclusive gene-content motifs.
Members of the antigenic variation super gene families such as the var, rifin and stevor, which show multi-exon organization, are dispersed mostly in the recombinogenic subtelomeric regions of different chromosomes and, for the most part, display mutually exclusive gene expression patterns.
Six mutually exclusive gene network modules were identified, labeled as colors: 'black', 'blue'turquoiseise'brown'wn'yellow'ow', and 'green'.
For example, two mutually exclusive gene cassettes, termed "BTFC and YLF", have been described that are dissimilar in their geographical distribution [ 12].
Two mutually exclusive gene clusters, B. thailandensis like flagellar gene cluster (BTFC) and Yersinia-like fimbrial gene cluster (YLF), have been linked to geographic origin and have been suggested for differentiating groups of B. pseudomallei (9 ).
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Justyna Jupowicz-Kozak
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