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These data demonstrate the power of MiDReG in predicting functionally important intermediate genes in a given developmental pathway that is defined by a mutually exclusive gene expression pattern.
Members of the antigenic variation super gene families such as the var, rifin and stevor, which show multi-exon organization, are dispersed mostly in the recombinogenic subtelomeric regions of different chromosomes and, for the most part, display mutually exclusive gene expression patterns.
Six mutually exclusive gene network modules were identified, labeled as colors: 'black', 'blue'turquoiseise'brown'wn'yellow'ow', and 'green'.
For example, two mutually exclusive gene cassettes, termed "BTFC and YLF", have been described that are dissimilar in their geographical distribution [ 12].
Such differences in sequence divergence may indicate functional divergence, which is demonstrated by the significant difference between the Brassicaceae AGG1 and AGG2 orthologue groups that have mutually exclusive gene expression patterns [ 21].
This model proposes a novel logic in mutually exclusive gene expression and provides us with an informed working hypothesis for further functional dissection of the mechanisms orchestrating singular var gene choice.
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For both tools I limited the search for mutually exclusive genes to size two and filtered the altered genes to take into account for mutual exclusivity by the list of TFs and partners integrating the circuits assessed in each tumor type.
As part of that expansion both 2DS4 and 2DL5 were moved into the telomeric region, but as part of different and mutually exclusive gene-content motifs.
The authors need a better illustration showing that mutually exclusive genes were enriched in top quartile of essential genes.
Experimental evolution of bacterial species constructed to have mutually exclusive genes by means of genetic engineering may be effective in verification of our models.
This report suggests how frequent the recombination events should occur among the meningococcal population: even theoretical mutually exclusive genes can produce hybrid variants; such knowledge is an important step in the development of future vaccines based on protein formulations.
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