Sentence examples for mutually exclusive complexes from inspiring English sources
Moreover, recent studies indicate that BRCA1/BARD1 selectively associates with several components of the DNA damage response forming mutually exclusive complexes.
When lysates from cells expressing all three proteins were immunoprecipitated (IP), a Mad IP (anti T7) failed to pull down Arm (Fig. 5H) and an Arm IP (anti HA) failed to pull down Mad (Fig. 5I), suggesting that the precipitates seen in Fig. 5F, G (lanes 2, 3) represent mutually exclusive complexes of dTcf/Arm and dTcf/Mad.
Through its BRCT phospho-binding ability BRCA1 forms at least three mutually exclusive complexes by binding to phosphorylated proteins Abraxas, Bach1 and CTIP.
Moreover, we have shown that the enhancer (ESE) domain forms several mutually exclusive complexes in nuclear extracts and that it forms a quadruplex.
The carboxy-termini are significantly more divergent, which may explain why MTA1, MTA2 and MTA3 are found in mutually exclusive complexes and are implicated in different signalling pathways [ 14].
Interestingly, Rnd3/14-3-3 and Rnd3/p190RhoGAP-B were in two mutually exclusive complexes: immunoprecipitates of p190RhoGAP-B contained Rnd3 but not 14-3-3 14-3-3 14-3-3 conversely immunoproteinsands of 14-3-3 proteins converselyRnd3 but not p190RhoGAP-B.
mTOR exists in two mutually exclusive protein complexes referred to as mTORc1 and mTORc2.
The main PCP components Van Gogh/Strabismus, Prickle, Frizzled, and Dishevelled were originally identified in Drosophila epithelia and shown to form mutually exclusive protein complexes that are localized to opposite sides of each epithelial cell (Devenport, 2014; Peng and Axelrod, 2012; Simons and Mlodzik, 2008; Wang and Nathans, 2007).
Despite their high overall homology (approximately 75% identity at the amino acid level), the BRG1 and BRM sequences diverge at the N-terminal region; these sequences regulate their binding to different transcription factors, and they form mutually exclusive SWI/SNF complexes.
These two proteins are mutually exclusive in SWI/SNF complexes and have been named after the Drosophila homologue Brahma as BRG1 (Brahma-related gene-1, SMARCA4) and the related protein BRM (SMARCA2).
As the ARID1A and ARID1B proteins are mutually exclusive in SWI/SNF complexes, it seems that a distortion of the balance of these proteins may be the driver of further pathophysiological processes.
