Sentence examples for mutually exclusive activation from inspiring English sources

Although the exact function of this interaction remains to be discovered, binding of MIF to the mutual exclusion element may earmark var loci for mutually exclusive activation.

To test this hypothesis and to identify such functional elements we investigated if any of the activated truncated promoters escaped mutually exclusive activation.

Together, this series of experiments pinpointed a putative 101 bp mutual exclusion element (MEE) (bps −316 to −215) that drives the upsC promoter into mutually exclusive activation; in absence of the MEE promoters escape this restriction and are activated in parallel to endogenous var transcription.

Here, we employed a functional approach to dissect the role of var gene upstream regions in mutually exclusive activation.

This mutually exclusive activation confers an interesting character to ceRNAs as potential oncosuppressive, or oncogenic, protagonists in cancer.

A significant correlation between activation of the Wnt pathway and mutually exclusive activation of either the PI3K or MAPK signalling pathways was observed (P<0.0001).

Interestingly, the fact that this element functions autonomously in a euchromatic context implies a ubiquitous rather than spatially restricted distribution of the transcriptional activator involved, which somewhat precludes a restricted role for this factor in mutually exclusive var activation.

The specific binding of a nuclear factor or complex (MIF) to a cis-acting sequence motif present in this region (MEE2) corroborates this hypothesis and suggests an important role for this DNA protein interaction in mutually exclusive promoter activation.

Analysis of co-occurrences of mutations in the PI3K and MAPK signalling pathways demonstrated that unlike BRAF and K-RAS mutations, acting as mutually exclusive mechanisms of activation of the same signalling pathway, oncogenic PIK3CA activation and PTEN loss are not equivalent.

CDH1 inactivation is mutually exclusive to PTK2 activation in breast cancer (p-value = 0.001).

Based on these novel findings, and by integrating current knowledge, we propose a speculative mechanistic model for mutually exclusive var gene activation (Fig. 6).