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We have subsequently categorized the mutual targets of Oct4 and Nanog according to the pattern of their combinatorial effect.
Moreover, these mutual targets of LIN-35 and MES-4 included many intestine-associated genes along with germline genes.
To obtain a more accurate description of the binding mechanism, in addition to the unconstrained target genes shared by a set of TFs, also mutual targets were considered that allowed for colocalization of the TFs.
Similarly, to visualise the proteomic changes, we created heatmaps highlighting the mutual targets induced by KSR1 in response to doxorubicin or etoposide, as well as the ones exclusively belonging to either Doxo-KSR1 or Etop-KSR1 (Fig. 2d).
Furthermore, IGF1R and mTOR are mutual targets of miR-100 and miR-99a in several cancer cells (Doghman et al, 2010; Lerman et al, 2011; Sun et al, 2011), and they have been implicated in the initiation and progression of several malignant neoplasms (Petroulakis et al, 2006), including ALL (Cardoso et al, 2009; Medyouf et al, 2011).
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They take initiations to carry out desired activity and also respond to other agents to meet a mutual target.
The cytoskeleton thus emerges as a potential mutual target in plant pathogen combats that appears to be under attack by effector molecules from both sides.
Thus, the existence, if any, of a mutual target for MMP-13 and uPA, which is functionally involved in keratinocyte migration still remains to be determined.
In addition, miR-290-295 co-regulate mutargetargenesenes along with these same TFs.
This is in line with the fact that the knock-down of either of the two transcription factors will decrease the expression levels of the mutual target genes and start the differentiation process [ 4].
Other possibilities may also regulate the interplay of Osa and Wg signaling, such as mutual transcriptional regulation of common target genes (Baig et al. 2010).
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