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In summary, our results indicate that mutual repression between hb and kni is conserved, but the strength of these repressive interactions differs considerably between M. abdita and D. melanogaster: we detect weaker inhibition of kni by hb and stronger inhibition of hb by kni.
The system of mutual repression between Wg and Dpp described here, provides a mechanism for maintaining separate "territories" of wg and dpp expression in a developing field.
The structure and symmetries of the network are clear, for instance the mutual repression between R2 and R4, and the repression of R1 by R2 and R3 by R4.
A circuitry involving mutual repression between three miRNAs and a key protein regulator has been described to control monocyte differentiation.
Our findings indicate a crucial role for mutual repression between Pax6 and Shh in diencephalic cell specification.
In addition, it has recently been shown that the mutual repression between PXR and NF-κB signalling pathways provides a molecular mechanism linking xenobiotic metabolism and inflammation [ 48].
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Mutual repression of signalling between NFκB and ER has been reported in various in-vitro systems (Harnish et al., 2000; Feldman et al., 2007; Quaedackers et al., 2007).
Jaeger et al. [ 45] suggested that non-overlapping gap gene are mutually exclusive and have mutual repression.
Domains of hb and kni as well as Kr and gt have mutually exclusive expression patterns and show strong mutual repression.
10.7554/eLife.07389.038 Author response image 2. DOI: http://dx.doi.org/10.7554/eLife.07389.038 New data added on the relationship between EcR and miR965: While exploring the relationship between EcR and miR-965, we've made an interesting new finding: EcR and miR-965 appear to be linked in a mutual repression feedback loop in which EcR and miR-965 repress each other.
The mathematical model of a mutual repression circuit has previously been applied to describe the dynamics of the switch between the lysogenic and lytic phases of the lifecycle of bacteriophage lambda (Ptashne, 2004), and a genetically engineered toggle switch circuit in Escherichia coli (Gardner et al., 2000).
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