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Additionally, the regulation of phosphate-activated glutaminase (GLS2) reveals that p53 may have a role in modulating glutamine metabolism (Hu et al., 2010; Suzuki et al., 2010), and the mutual regulation of malic enzymes (MEs) and p53 demonstrates that p53 rigorously regulates and couples glutamine metabolism to cell fate decisions.
Tian, L. et al. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming.
Our study unearths a key mechanism underlying autolysosome formation, a process in which the kinase activity of PKCα plays an instrumental role, and reveals the significance of the mutual regulation of macroautophagy and CMA in maintaining the balance of autophagy.
Demonstration of the mutual regulation of macroautophagy and CMA integrated by the protein kinase activity of PKCα revealed that PKCα has a significant role in maintaining the balance of autophagy and is an attractive molecular target for autophagy-related human diseases.
We propose models depicting the mutual regulation of SFKs and TrkB following activation of TrkB by zinc and BDNF.
Cellular and neuritic morphology is modulated through mutual regulation of the actin and microtubule cytoskeleton.
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For example FOXO exerts positive feedback on its own synthesis [ 100], and there are additional mutual regulations of FOXO, Akt and PP2A [ 101, 102].
Interestingly, although there are 11 pairs of homolog hub pairs without mutual regulation, none of them leaded to a significant coregulation.
We present evidence for mutual regulation and entrainment of the interaction, and we discuss how this benefits the interaction as a whole.
Indeed, their relative expression patterns suggest that the regulation of posterior segments may be through the type of mutual regulation described for the pair-rule gene circuit of Tribolium.
As a result of mutual regulation by both miRNAs and TFs, gene regulation is assembled within the structure of a network.
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