Nevertheless, it is noteworthy that the transcription factors identified in the current analysis showed sequential time-dependent expression and mutual regulation, and that these functions are regulated by upstream ERK signals.
As such, the mutual regulation between transcription factors and microRNAs regulate the bistable state between progenitor maintenance and myeloid development, where repression of inhibitory miRNA by histone demethylation of its promoter is associated with macrophage differentiation.
Mutual regulation is strongest between intimate pairs, but human beings regulate each other collectively as well.
Additionally, the regulation of phosphate-activated glutaminase (GLS2) reveals that p53 may have a role in modulating glutamine metabolism (Hu et al., 2010; Suzuki et al., 2010), and the mutual regulation of malic enzymes (MEs) and p53 demonstrates that p53 rigorously regulates and couples glutamine metabolism to cell fate decisions.
Engineers meeting here for the first public technical session about the Aug. 14 blackout said on Tuesday that to avoid a recurrence, the industry should be more tightly linked, through mutual regulation and data sharing, though the path to that point was unclear.
However, even in these cases mutual regulation is required.
Cellular and neuritic morphology is modulated through mutual regulation of the actin and microtubule cytoskeleton.
In conclusion, we have revealed mutual regulation between the tumor suppressor PTEN and the microRNA miR-22.
Our assay may be developed as sophisticated approaches for studying the mutual regulation of miRNAs and mRNAs in vitro and in vivo.
Interestingly, although there are 11 pairs of homolog hub pairs without mutual regulation, none of them leaded to a significant coregulation.
A general consensus indicates that such switches are based on a mutual regulation of two transcription factors (figure 1), e.g. mutual inhibition: protein A inhibits the synthesis of protein B and vice versa [12].
