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It is important to notice that mutual information approaches do not allow for determining the directionality of the links; for light and dark grey links the directionality was assessed based on comparison with the Gold Standard to simplify the figure.
Each reverse-engineering method has specific features and can be suitable for different needs: for example, Bayesian networks can provide statistically rigorous results but at the price of high computational costs, whereas mutual information approaches are computationally fast but are limited mostly by the lack of directionality of the inferred links.
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The mutual information approach thus provides an indirect signature of the existence of correlations between different parts of the random fibre laser spectrum.
This involves finding the SINR in each channel estimation tile and averaging these SINR values over all tiles using an equivalent mutual information approach [39].
From these pairs, by a mutual information approach, we found 4 pairs of pathways potentially targeted by 12 miRNAs.
Some novel connections, such as Ribosomal S6 kinase for Tumor Necrosis Factor alpha are also identified by the mutual information approach, which were not detected by the PCR approach.
The increased efficiency of our algorithm improves the feasibility of applying mutual information based approaches for reconstructing large regulatory networks.
With respect to correlation or mutual information based approaches, these methods are potentially able to model higher-order dependencies between the expression patterns of genes.
Mutual information based approaches are most useful for large-scale network inference.
The mutual information (MI ESMM approach is used in this paper.
Since the stability condition ensures the asymptotic convergence to the zero-error state for a given input messages, is valid and required only when the output mutual information will approach 1 at the input mutual information.
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