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V. cholerae strains have little mutual gene content variation even in the hypervariable superintegron region (see chromosome II midpoint 375 Kb).
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Comparison of gene content among twelve Paratyphi A strains.
We then annotated these segments for gene and cancer gene content using our clinical pipeline.
Animal mt genomes are usually extremely stable in terms of gene content, gene arrangement and genome organization23,25.
Therefore, their gene content is not unique.
The fact that these bacteria inhabit a common niche in plants could facilitate mutual gene exchange.
The definition of the mutual gene module of disease is based on the Gene Ontology Cellular Component Terms and Gene Ontology Biological Process Term.
However, few studies attempt to discover the mutual gene modules shared by the drug and disease association.
This study highlights substantial mutual discrepancies among different pathway sources, e.g. with regard to pathway sizes, names and gene contents.
Functionally linked genes in this study are defined as the genes that satisfy thecutoff criteria of 0.9 for mutual information content and 0.8 for Pearson correlation coefficient as these values differentiated the real from random data.
Functionally linked genes were inferred based on calculation of mutual information content using mis_calc program [31], Pearson correlation coefficient and Hamming distance (using an in-house developed perl script).
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