Sentence examples for mutual exclusivity between from inspiring English sources
The reviewers pose an excellent question – mutual exclusivity between SPOP mutations and BRCA2 and ATM mutations described in the SU2C/PCF cohort (Robinson et al., Cell 2015) of CRPC samples would support a continued role of SPOP mutation in compromised DNA repair in CRPC.
In our study, a trend was seen towards mutual exclusivity between PIK3CA mutations and p53 mutations (P=0.0687).
Several other intriguing observations have been noted, including a tendency toward co-occurrence between mutations in ARID1A and CTNNB1 (β-catenin) or PI3K-Akt pathway alterations, as well as a mutual exclusivity between ARID1A and TP53 mutations (Bosse et al., 2013).
In other words, there is a phenomenon of mutual exclusivity between driver mutations.
A recent report indicates mutual exclusivity between activation of the PI3K pathway and IDH1 activity [ 20].
Mutual exclusivity between frequently occurring genetic events identifies synthetic lethal combinations in cancers.
A mutual exclusivity was observed between KRAS and BRAF mutations (P=0.0183).
The new approach hinges on the observation that there seems to be an inverse correlation between gene essentiality and mutual exclusivity of co-occurrence of genomic events with mutated tumor suppressor genes in the studied cell lines (right side panel of Fig. 3).
We observed mutual exclusivity or co-occurrence of events within and between several dysregulated EAC pathways, a result suggestive of strong functional relationships.
For all cell lines harbouring deficiencies in ATM, BRCA1, BRCA2, PTEN and TP53 we see a downward trend, thereby indicating a strong agreement between the rankings based on mutual exclusivity and the GARP essentialities of our predicted genes B in gene A-deficient cell lines (no data are available for cell lines with CDH1 deficiency).
This mutual exclusivity of stable gene expression patterns ensures definitive separation between two discrete cellular phenotypes and an all-or-none response in individual B cells to antigen stimulation.
