Sentence examples for mutations yielding a from inspiring English sources

In turn, mutations yielding a "gain of uORF function" in tumor suppressor genes may result in malignant transformation due to a decreased production of protective proteins (Fig. 5).

Amongst these, mhttQ51 is of particular interest since mutations yielding a polyQ tract longer than ∼58Q are rare in patients (Myers 2004) and N-terminal fragments of similar length (mhttQ53) have been isolated from brain tissue of patients (Lunkes et al., 2002).

In this whole exome screen, we identified 490 non-synonymous and 260 synonymous mutations, yielding a ratio of non-synonymous to synonymous changes (N/S ratio) of ~1.9 1; which is not higher than the N/S ratio of 2 1 predicted for non-selected passenger mutations [ 14], suggesting that most of these alterations are likely to be 'passenger' mutations.

In this population-based study of 290 patients diagnosed with prostate cancer before age 55 years, there were two patients with germline protein-truncating BRCA2 mutations, yielding an overall prevalence of 0.69% (95%CI 0.08 2.49%).

The novel eleventh locus we have designated as nonHMG Sry due to a frame shift mutation yielding a protein with an incomplete HMG box.

However, of all the SNPs identified, substitution of the serine at position 1076 with an isoleucine appears to be the most detrimental mutation, yielding a drug sensitivity shift to KAF156 of >700-fold.

CD22ΔE12 results in a truncating frame shift mutation yielding a mutant CD22ΔE12 protein that lacks most of the intracellular domain including the key regulatory signal transduction elements, such as the ITIMs that provide docking sites for the SH2 domains of SHP1, and all of the cytoplasmic tyrosine residues (Uckun et al., 2010).

In view of the fact that spontaneous mutations yielding target-dependent Rif-resistance are a major problem in antibacterial therapy with Rif (Ho et al., 2009), the smaller size of the GE target-based resistance spectrum is a potentially important advantage.

This shift in the elution volume is consistent with the interface-disrupting mutations yielding monomeric ComFB.

Namely, the frequency of spontaneous mutations yielding target-dependent GE-resistance is expected to be unusually small (∼1/10 to ∼1/5 the frequency of spontaneous mutations yielding target-dependent resistance to Rif and other RNAP inhibitors).

Results show that the pattern of combinations of mutations yielding the different CYP1A1 variant alleles in the present study differs from that reported for Caucasians.